Systemic inflammatory response syndrome, thromboinflammation, and septic shock in fetuses and neonates
Bitsadze V., Lazarchuk A., Vorobev A., Khizroeva J., Tretyakova M., Makatsariya N., Gashimova N., Grigoreva K., Tatarintseva A., Karpova A., Mostovoi A., Zainulina M., Kapanadze D., Blbulyan A., Kuneshko N., Gris J.-C., Elalamy I., Gerotziafas G., Makatsariya A.
Abstract
This article explores systemic inflammatory response syndrome (SIRS), thromboinflammation, and septic shock in fetuses and neonates, offering a comprehensive examination of their pathophysiology, diagnostic criteria, and clinical implications. It identifies SIRS as an exaggerated response to external stress, disrupting the balance between inflammation and adaptive mechanisms, driven by cytokines such as TNF-α and IL-1. The fetal inflammatory response syndrome (FIRS), a subset of SIRS, is noted for its role in adverse neonatal outcomes, including organ damage, inflammation, and long-term developmental disorders. The article discusses the extensive effects of FIRS on critical systems, including the blood, lungs, central nervous system, and kidneys. It highlights the challenges in diagnosing and managing septic shock in neonates, focusing on the relationship between inflammation and the hemostatic system. Additionally, the paper points out recent advancements, such as the convergent model of coagulation and emerging biomarkers like microRNAs for early detection. Despite this progress, gaps remain in understanding the molecular mechanisms underlying these conditions and in developing effective therapeutic strategies. This highlights the necessity for targeted research to mitigate the morbidity and mortality associated with septic shock in neonates.
For citation: Bitsadze, V., Lazarchuk, A., Vorobev, A., Khizroeva, J., Tretyakova, M., Makatsariya, N., Gashimova, N., Grigoreva, K., Tatarintseva, A., Karpova, A., Mostovoi, A., Zainulina, M., Kapanadze, D., Blbulyan, A., Kuneshko, N., Gris, J.-C., Elalamy, I., Gerotziafas, G., & Makatsariya, A. (2025). Systemic Inflammatory Response Syndrome, Thromboinflammation, and Septic Shock in Fetuses and Neonates. International Journal of Molecular Sciences, 26(7), 3259. https://doi.org/10.3390/ijms26073259